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Immune System Modelling and Simulation by Filippo Castiglione, Franco Celada (Hardcover, 2015)

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The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunologist Franco Celada. This model was built around the idea of developing a computerized system to perform experiments similar in vivo experiments; a tool developed to help biologists testing theories and hypothesis about how the immune system works. C-ImmSim is best viewed as a collection of models in a single program. It incorporates the principal core facts of today's immunological knowledge, such as the diversity of specific elements, MHC restriction, clonal selection, thymic education of T cells, antigen processing and presentation (both the cytosolic and endocytic pathways are implemented), cell-cell cooperation, homeostasis of cells created by the bone marrow, hyper mutation of antibodies, maturation of the cellular and humoral response, and memory. Besides, an antigen can represent a bacterium, a virus, or an allergen or a tumor cell. C-ImmSim has been recently customized to simulate the HIV-1 infection. Moreover, it can simulate the immunotherapy for cancer. These features are all present in the code and people can choose to turn them on and off at compiling time. The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used in practice to produce new knowledge either from hypothesis or from lab-experiment data. In this respect, the book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.

Product Identifiers

Publisher
Taylor & Francis Inc
ISBN-13
9781466597488
eBay Product ID (ePID)
212138229

Product Key Features

Author
Filippo Castiglione, Franco Celada
Publication Name
Immune System Modelling and Simulation
Format
Hardcover
Language
English
Subject
Medicine
Publication Year
2015
Type
Textbook
Number of Pages
286 Pages

Dimensions

Item Height
234mm
Item Width
156mm
Item Weight
567g

Additional Product Features

Title_Author
Franco Celada, Filippo Castiglione
Country/Region of Manufacture
United States

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Immune System Modelling and Simulation by Filippo Castiglione, Franco Celada (Hardcover, 2015)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Time Management by Peter Quarry (Paperback, 1986)

Complete Illustrated Encyclopedia of Dinosaurs & Prehistoric Creatures by Dixon Dougal (Paperback, 2014)

Polyvagal Exercises for Safety and Connection: 50 Client-Centered Practices by Deb Dana (Paperback, 2020)

Save on Adult Learning & University

Ford Falcon EF EL / Fairlane NF NL 1994 - 1998 Workshop Manual

Netter Atlas of Human Anatomy: Classic Regional Approach

Sapiens A Brief History of Humankind by Yuval Noah Harari Paperback Book NEW

BORN IN 1971?... 1951?BIRTHDAY...Australian Social History....Chrisi, Birthdays

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