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Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation by Stephen Burgess, Simon G. Thompson (Hardcover, 2015)

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Presents the Terminology and Methods of Mendelian Randomization for Epidemiological Studies Mendelian randomization uses genetic instrumental variables to make inferences about causal effects based on observational data. It, therefore, can be a reliable way of assessing the causal nature of risk factors, such as biomarkers, for a wide range of disease outcomes. Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization spanning epidemiology, statistics, genetics, and econometrics. Although the book mainly focuses on epidemiology, much of the material can be applied to other areas of research. Through several examples, the first part of the book shows how to perform simple applied Mendelian randomization analyses and interpret their results. The second part addresses specific methodological issues, such as weak instruments, multiple instruments, power calculations, and meta-analysis, relevant to practical applications of Mendelian randomization. In this part, the authors draw on data from the C-reactive protein Coronary heart disease Genetics Collaboration (CCGC) to illustrate the analyses. They present the mathematics in an easy-to-understand way by using nontechnical language and reinforcing key points at the end of each chapter. The last part of the book examines the potential of Mendelian randomization in the future, exploring both methodological and applied developments. This book gives statisticians, epidemiologists, and geneticists the foundation to understand issues concerning the use of genetic variants as instrumental variables. It will get them up to speed in undertaking and interpreting Mendelian randomization analyses. Chapter summaries, paper summaries, web-based applications, and software code for implementing the statistical techniques are available on a supplementary website.

Product Identifiers

Publisher
Taylor & Francis Inc
ISBN-13
9781466573178
eBay Product ID (ePID)
189358923

Product Key Features

Author
Stephen Burgess, Simon G. Thompson
Publication Name
Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation
Format
Hardcover
Language
English
Subject
Biology, Mathematics, Healthcare System
Publication Year
2015
Type
Textbook
Number of Pages
224 Pages

Dimensions

Item Height
234mm
Item Width
156mm
Item Weight
454g

Additional Product Features

Title_Author
Stephen Burgess, Simon G. Thompson
Series Title
Chapman & Hall/Crc Interdisciplinary Statistics
Country/Region of Manufacture
United States

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Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation by Stephen Burgess, Simon G. Thompson (Hardcover, 2015)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Time Management by Peter Quarry (Paperback, 1986)

Complete Illustrated Encyclopedia of Dinosaurs & Prehistoric Creatures by Dixon Dougal (Paperback, 2014)

Polyvagal Exercises for Safety and Connection: 50 Client-Centered Practices by Deb Dana (Paperback, 2020)

Save on Adult Learning & University

Ford Falcon EF EL / Fairlane NF NL 1994 - 1998 Workshop Manual

Netter Atlas of Human Anatomy: Classic Regional Approach

Sapiens A Brief History of Humankind by Yuval Noah Harari Paperback Book NEW

BORN IN 1971?... 1951?BIRTHDAY...Australian Social History....Chrisi, Birthdays

Michael Price Nick Vandome Windows 11 for Seniors in easy steps (Paperback)

It's Not You: How to Identify and Heal from NARCISSISTIC People by Ramani Durvas

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