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Sustained Release Tablets by Tariq Mahmood, Akhtar Rasul, Barkat Ali Khan (Paperback, 2011)

About this product

About this product

Product Information

The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline cellulose (MCC) was used as diluent. The polymer was incorporated into a matrix system using direct compression technique. Different formulations were evaluated with respect to dissolution profile in 900 mL phosphate buffer (pH 6.8), 0.1 M HCl solution and distilled water for 12 h at 37 DegreesC. Increasing the amount of polymer (xanthan gum) in the formulation led to slow release of drug. The kinetic treatment showed the best fitted different mathematical models (Zero order, First order, Higuchiis and Hixson-Crowell). Most of the solid matrix formulations followed Higuchi or zero order kinetics. The formulations F1, F2, F3 and F7, F8, F9 showed maximum linearity. The results showed that the formulation F9 containing 30% xanthan gum and 10% gum tragacanth is the most similar to that of the reference marketed preparation.

Product Identifiers

Publisher
Lap Lambert Academic Publishing
ISBN-13
9783844323719
eBay Product ID (ePID)
107807888

Product Key Features

Author
Tariq Mahmood, Akhtar Rasul, Barkat Ali Khan
Publication Name
Sustained Release Tablets
Format
Paperback
Language
English
Subject
Healthcare System
Publication Year
2011
Type
Textbook
Number of Pages
116 Pages

Dimensions

Item Height
229mm
Item Width
152mm
Item Weight
181g

Additional Product Features

Title_Author
Akhtar Rasul, Tariq Mahmood, Barkat Ali Khan
Country/Region of Manufacture
Germany

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