Individual organisms are de?ned by their genetic code. During development andasaresponsetoexternalstimulithegeneticinformationistranslated into awell-de?nedanswerresultingintheexpressionandmodi?cationofproteins. The processes that control protein-protein interactions (PPI) are presently mostly described in terms of individual protein-protein interactions. In vivo suchinteractions are partof complex molecular interaction networksthat are highlydynamicintimeandspace.Onthebasisofquantitative experiments, it would be possible to understand such complex biological systems leading to anunravelingofthesenetworksandallowingthemtobecaughtinquantitative and predictive models. This textbook illustrates the rise of a relatively new area of biology. The shifting of research from the structural assembly of cells and whole org- isms to metabolic diversity led to the beginning of interactomics. This ?eld hasarisenfromtheincreasingimportanceofmolecularbiologyandbioch- istry in basic research as well as in prognostics and prevention of diseases in connection withbiomarker development. The behavior, morphology, and response to stimuli in biological systems arepredetermined bytheinteractionsbetweentheircomponents.Theseint- actions, as we observe them now, are therefore shaped by genetic variations and selective pressure. With the understanding of molecular interactions the biologyisgettingeasier tosurvey.Thecharacterizationofproteininteractions cancontribute to the understanding ofmany processes in nature. Knowledgeofthedifferenttypesofbiologicalmacromoleculesandincre- ingnumbersofwholegenomicstudiesfacilitatetheelucidationofcellularp- cesses. Whether it is genomics, transcriptomics, proteomics, interactomics, or metabolomics, the full complement of genomic information at different levels can be compared between different organisms to reveal similarities or differences and even to provide consensus models.
Product Identifiers
Publisher
Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
ISBN-13
9783540688174
eBay Product ID (ePID)
95779341
Product Key Features
Subject Area
Bioengineering
Author
MeiKe Werther, Harald Seitz
Publication Name
Protein-Protein Interaction
Format
Hardcover
Language
English
Subject
Medicine, Chemistry, Biology
Publication Year
2008
Type
Textbook
Number of Pages
272 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Volume
110
Item Weight
653g
Additional Product Features
Series Title
Advances in Biochemical Engineering/Biotechnology
Editor
Harald Seitz, MeiKe Werther
Country/Region of Manufacture
Germany
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