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About this product
- DescriptionHistorically, the major emphasis on the study of purinergic systems has been predominantly in the areas of physiology and gross pharmacology. The last decade has seen an exponential in- crease in the number of publications related to the role of both adesine and A TP in mammalian tissue function, a level of interest that has evolved from a more molecular focus on the identity of adesine and A TP receptor subtypes and the search for selective ligands and development of radioligand binding assays by Fred Bruns and colleagues (especially that for A receptors) that played z a highly significant role in advancing research in the area. In the 60 years since adesine was first shown to be a potent hypotensive agent, a considerable investment has been made by several pharmaceutical companies-including Abbott, Byk Gulden, Takeda, Warner-LambertlParke Davis, Boehringer Mann- heim, Boehringer Ingelheim, Nelson/Whitby Research and CffiA- Geigy-as well as John Daly's laboratory at the National Institutes of Health, to design new adesine receptor ligands, and both agon- ists and antagonists with the aim of developing new therapeutic entiities. Numerous research tools have derived from these efforts including: 2-chloroadesine, R-PIA (~-phenylisopropylade- sine; NECA (5' N-ethylcarboxamidoadesine); CV1808; CI936; PD 125,944; ~-benzyladesine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680. Yet in the realm of therapeutics it was only in 1989 that adesine itself was approved for human use in the treatment of supraventricular arrythmias.
- Author(s)Michael Williams
- PublisherHumana Press Inc.
- Date of Publication11/06/1990
- SubjectLife Sciences: General
- Series TitleThe Receptors
- Place of PublicationTotowa, NJ
- Country of PublicationUnited States
- ImprintHumana Press Inc.
- Content Notebiography
- Weight918 g
- Width152 mm
- Height229 mm
- Spine28 mm
- Format DetailsLaminated cover
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