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About this product
- DescriptionOncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-automous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are soft-wired , i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-kwn mutations in cancer genes profoundly affect tumor milieu. In fact, these n-cell-automous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication07/03/2012
- SubjectClinical Medicine: Professional
- Series TitleCancer Genetics
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Note29 black & white illustrations, 16 colour illustrations, 9 black & white tables, biography
- Weight777 g
- Width155 mm
- Height235 mm
- Spine26 mm
- Edited byAndrei Thomas-Tikhonenko
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