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- DescriptionNasopharyngeal carcimas (NPC) are human epithelial tumors constantly associated with the Epstein-Barr virus. However it was kwn that these cells were producing in vitro exosomes carrying the galectin 9 protein. Galectin 9 is an agonist of the Tim-3 receptor, a pro-apoptotic receptor carried by the mature CD4 + Th1 lymphocytes. Our data show that NPC exosomes carrying galectin 9 behave as agonists of the Tim-3 receptor. They are selectively detected in the plasma of xegrafted mice or patients with NPC. In vitro they induce massive apoptosis of cells derived from CD4 + Th1 lymphocyte clones expressing Tim-3 and used as a model of cellular targets. This effect is inhibited by pre-incubating either the target cells with an anti-Tim-3 blocking antibody or the exosomes with an anti-galectin 9 antibody. Overall, our work suggests that NPC exosomes carrying galectin 9 play an important role as a factor of immusuppression in NPC patients. Patient treatment with anti-galectin 9 antibodies might be beneficial in combination with some protocols of adoptive immutherapy.
- PublisherUniv Europeenne
- Date of Publication03/11/2010
- FormatPaperback / softback
- SubjectLife Sciences: General
- Series TitleOmn.Univ.Europ.
- Country of PublicationUnited States
- ImprintUniv Europeenne
- Content Noteblack & white illustrations
- Weight209 g
- Width152 mm
- Height229 mm
- Spine8 mm
- Format DetailsTrade paperback (US),Unsewn / adhesive bound
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