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About this product
- DescriptionMost of the cancer patients die because the tumoral cells do t stick in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors conspire to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is w the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication09/06/2005
- SubjectLife Sciences: General
- Series TitleCancer Metastasis - Biology and Treatment
- Series Part/Volume Numberv. 7
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Notebiography
- Weight631 g
- Width155 mm
- Height235 mm
- Spine19 mm
- Edited byManel Esteller
- Format DetailsLaminated cover
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