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About this product
- DescriptionThe free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is t only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phemen. It was, therefore, felt that it is w timely to review our present kwledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell's various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut fur Strahlenchemie (w MPI fur Bioarganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
- Author BiographyBorn in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut fur Strahlenchemie, Mulheim. After retirement continuing collaboration with the Leibniz-Institut fur Oberflachenmodifizierung (IOM), Leipzig.
- Author(s)Clemens von Sonntag
- PublisherSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
- Date of Publication12/02/2010
- SubjectLife Sciences: General
- Place of PublicationBerlin
- Country of PublicationGermany
- ImprintSpringer-Verlag Berlin and Heidelberg GmbH & Co. K
- Content Note100 black & white tables, biography
- Weight825 g
- Width156 mm
- Height234 mm
- Spine27 mm
- Format DetailsTrade paperback (US)
- Edition StatementSoftcover reprint of hardcover 1st ed. 2006
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