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About this product
- DescriptionGenetic recombination, in the broadest sense, can be defined as any process in which DNA sequences interact and undergo a transfer of information, producing new recombinant sequences that contain information from each of the original molecules. All organisms have the ability to carry out recombination, and this striking universality speaks to the essential role recombination plays in a variety of biological processes fundamentally important to the maintenance of life. Such processes include DNA repair, regulation of gene expression, disease etiology, meiotic chromosome segregation, and evolution. One important aspect of recombination is that it typically occurs only between sequences that display a high degree of sequence identity. The stringent requirement for homology helps to ensure that, under rmal circumstances, a cell is protected from deleterious rearrangements since a swap of genetic information between two nearly identical sequences is t expected to dramatically alter a geme. Recombination between dissimilar sequences, which does happen on occasion, may have such harmful consequences as chromosomal translocations, deletions, or inversions. For many organisms, it is also important that recombination rates are t too high lest the geme become destabilized. Curiously, certain organisms, such as the trypasome parasite, actually use a high rate of recombination at a particular locus in order to switch antigen expression continually and evade the host immune system effectively.
- PublisherHumana Press Inc.
- Date of Publication09/01/2004
- SubjectLife Sciences: General
- Series TitleMethods in Molecular Biology
- Series Part/Volume Numberv. 262
- Place of PublicationTotowa, NJ
- Country of PublicationUnited States
- ImprintHumana Press Inc.
- Content Notebiography
- Weight601 g
- Width152 mm
- Height229 mm
- Spine19 mm
- Edited byAlan S. Waldman
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