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About this product
- DescriptionAfter the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research. In MFG-E8 and Inflammation, the editor and contributors have gathered a remarkable collection covering vel discoveries on the rapidly growing field of MFG-E8 and Inflammation which includes t only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field. MFG-E8 and Inflammation starts by describing the origin, structure, expression, functions and regulation of MFG-E8, and then continues thoughtfully exploring its potentiality as a marker for apoptotic, stressed and activated cells. The topics cover the cellular and physiological function of MFG-E8, especially its role in efficient phagocytosis of apoptotic cells, intestinal barrier function, blood cell homeostasis and coagulation, and in the maintenance of the intact vascular system. The role of MFG-E8 in macrophages, neutrophils, lymphocytes, dendritic cells, platelets, as well as n-hematopoietic cells is adequately described in the book. The chapters also contain several lucid discussions on the recent discoveries of the roles of MFG-E8 in the autoimmune diseases, sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel diseases, acute lung injury, asthma, lung fibrosis, stroke, prion diseases and Alzheimer's diseases with the potential focus on elucidating vel mechanistic pathways. MFG-E8 and Inflammation is an indispensable resource for scientists and clinical researchers working on fundamental or applied aspects of MFG-E8 pathobiology. This book explores, dissects and reviews several teworthy findings and striking future perspectives which t only rewrite the disease pathophysiology, but also update our understanding towards attaining vel therapeutic potentials against various inflammatory diseases.
- Author BiographyPing Wang, MD, is the Vice Chairman for Research at the Department of Surgery, and Professor of Surgery and Molecular Medicine at Hofstra North Shore-LIJ School of Medicine. He is also the Head of the Center for Translational Research at the Feinstein Institute for Medical Research. Previously, Dr. Wang has held positions of Associate Professor of Surgery at Brown University School of Medicine and Professor of Surgery, Pathology, Physiology and Biophysics at University of Alabama at Birmingham (UAB), as well as Professor of Surgery at Albert Einstein College of Medicine. His laboratory has been continually funded by the NIH since 1995. Dr. Wang has published over 300 peer-reviewed articles in the field of inflammation research.
- Date of Publication01/04/2014
- SubjectClinical Medicine: Professional
- Place of PublicationDordrecht
- Country of PublicationNetherlands
- Content Note9 black & white illustrations, 21 colour illustrations, 3 black & white tables, biography
- Weight496 g
- Width155 mm
- Height235 mm
- Spine18 mm
- Edited byPing Wang
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