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- DescriptionAbrmal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immutherapy. Precise identification of the mechanism leading to MHC class I defects will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is available on the changes in MHC class I expression during the course of cancer immutherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immutherapy depends on the molecular mechanism responsible for the MHC class I alteration and t on the type of immutherapy used. According to this tion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immutherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immutherapy.
- Author BiographyTeresa Cabrera Castillo, Ph.D., MD., is a Full Professor at the Department of Biochemistry, Molecular Biology, and Immunology at the University of Granada and a Medical Immunology Specialist at Hospital Universitario Virgen de las Nieves. Natalia Aptsiauri, Ph.D., MD., is a Senior Staff Scientist at the Department of Clinical Analysis and Immunology, University Hospital Virgen de las Nieves Angel Miguel Garcia Lora, Ph.D., is a Senior Staff Scientist at the Department of Clinical Analysis and Immunology, University Hospital Virgen de las Nieves Please see attached CVs for more detail.
- Author(s)Angel Miguel Garcia-Lora,Natalia Aptsiauri,Teresa Cabrera
- PublisherSpringer-Verlag New York Inc.
- Date of Publication22/02/2013
- SubjectClinical Medicine: Professional
- Series TitleSpringerBriefs in Cancer Research
- Series Part/Volume Number1
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Note3 black & white illustrations, 14 colour illustrations, biography
- Weight113 g
- Width155 mm
- Height235 mm
- Spine8 mm
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