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About this product
- DescriptionThis book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are w informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more n-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.
- Author BiographyJeremy Levin is currently a Director of Medicinal Chemistry at Boehringer Ingelheim Pharmaceuticals, with a total of 25 years of experience in the pharmaceutical industry. He has worked in multiple therapeutic areas, including CNS, inflammation and immunology, and oncology. Dr Levin has authored or co-authored more than 70 papers in peer reviewed journals and served as an inventor on more than 60 issued U.S patents.
- PublisherRoyal Society of Chemistry
- Date of Publication16/10/2014
- SubjectClinical Medicine: Professional
- Series TitleDrug Discovery
- Series Part/Volume Number40
- Place of PublicationCambridge
- Country of PublicationUnited Kingdom
- ImprintRoyal Society of Chemistry
- Content Note120 black & white illustrations, 20 colour illustrations
- Weight907 g
- Width156 mm
- Height234 mm
- Spine36 mm
- Edited byJeremy Levin
- Series Edited byDavid P. Rotella
- Format DetailsUnsewn / adhesive bound
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