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- DescriptionMembranes are highly dynamic and operate t only as inert boundaries, but the packages they carry around in a cell are well addressed fro appropriate delivery. This holds for a variety of endomembrane systems engaged in exo- and endocytosis, for organelles along the biosynthetic pathway, phagosomes, and lysosomes. It also holds for the establishment of functional surface properties. Cell pairing (conjugation) phemena are a good model for the problem of how a cell can discriminate between self and n-self . On the other hand parasitic sporozoa developed to experts in masking their molecular sur- face by frequent shedding of their variant antigens. The discovery of their glycosyl-phosphatidylisitol (GPI) anchor has led to the discovery, in polar epithelial cells, of a specific targeting mechanism for GPI-anchored surface glycoproteins. Over one hundred such proteins have been detected in metazoans since then. Many of these basic aspects are dealt with in this book using quite different methodical approaches. Of course, there are many more aspects previously kwn from metazoan systems and such aspects then had to be verified also for Protozoa systems and such aspects then had to be verified also for protozoa. In this context, it is fascinating to see how basic cellular functions are maintained - with variations of the basic theme - throughout evolution. However, sometimes cell biologists dedicated to work with protozoa have to live with a regrettable phemen. Colleagues working with higher eukaryotic cells are frequently unaware of the fact that the primary input may have come from work with protozoa. Some phemena may even be rediscovered inadvertently. In this sense, this book should address t only colleagues working with protozoa but also many of our fellow cell biologists working with metazoan cells.
- PublisherElsevier Science & Technology
- Date of Publication01/12/1993
- SubjectLife Sciences: General
- Series TitleAdvances in Cellular and Molecular Biology of Membranes and Organelles
- Series Part/Volume Numberv. 2
- Place of PublicationOxford
- Country of PublicationUnited Kingdom
- ImprintJAI Press Inc.
- Content NoteIllustrations
- Weight559 g
- Width150 mm
- Height230 mm
- Spine18 mm
- Edited byH. Plattner
- Volume editorAlan Michael Tartakoff
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