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- DescriptionThe ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been kwn for some time, it is only in recent years through advances in geme sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer's amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication23/06/2005
- SubjectLife Sciences: General
- Series TitleProteases in Biology and Disease
- Series Part/Volume Numberv. 4
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Notebiography
- Weight681 g
- Width155 mm
- Height235 mm
- Spine20 mm
- Edited byN. M. Hooper,Uwe Lendeckel
- Format DetailsLaminated cover
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