The Promises and Challenges of Regenerative Medicine by Springer-Verlag Berlin and Heidelberg GmbH & Co. KG (Hardback, 2005)
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- DescriptionIthaslongbeenkwnthatamphibiaandotherlowerordervertebrates havethecapacitytoregeneratelimbsaswellasdamagedheartsorbrains. Overthepastdecade,therehasbeenamajorchangeinthewaythatthe potentialforregenerationinmammalsisviewed.Earlier,incontrastto the acceptance of regeneration in amphibia, it was generally believed that there was very limited if any capacity for regeneration in many mammaliargansystemssuchastheheartandbrain.Thediscoveryof tissue-resident adult stem cells and the description of the properties of embryonic stem cells have altered this view. This change in paradigm VI Preface has led to the hope that these discoveries can be harnessed in medical practicetocurechronicdisablingdiseases. The use of tissue-resident adult stem cells depends on the ability to either mobilize them or to convert them from one lineage to ather. These problems do t arise with embryonic stem cells. Instead, their useisfraughtwithethicalandpoliticalissuesaswellasthequestiof howtodirecttheirdifferentiationtowardthedesiredcelltype.Whichever approachistaken,issuesofsafetyhavetobeparamount.Inparticular,the roleofstemcellsintumorigenesisiscriticalinassessingtheirpotential clinicalutility. The Ernst Schering Research Foundation and the Riken Center on DevelopmentalBiologyjointlyorganizedaworkshopon ThePromises andChallengesofRegenerativeMedicine, whichtookplaceinKobe, Japan on 20-22 October 2004. The purpose of the workshop was to discuss the present state of kwledge and future directions in this important ?eld. Leading basic scientists and clinicians reviewed and discussedseveraltimelytopicswithinthreemainthemes:(1)evolution, development,andregeneration,includingstemcellsinPlanariaandstem cell niches; (2)embryonic and adult stem cells, including adiscussion of the regulatory system in Japan for human embryonic stem cells; and (3) regeneration in speci?c indications including a discussion of the role of stem cells in organs such as the skin, brain, liver, pancreas, cornea,andthecardiovascularsystem.Inaddition,theroleofstemcells in glioblastoma was presented along with the implications for other tumors.
- PublisherSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
- Date of Publication06/07/2005
- SubjectLife Sciences: General
- Series TitleErnst Schering Foundation Symposium Proceedings
- Series Part/Volume Numberv.54
- Place of PublicationBerlin
- Country of PublicationGermany
- ImprintSpringer-Verlag Berlin and Heidelberg GmbH & Co. K
- Content Note10 black & white tables, biography
- Weight406 g
- Width155 mm
- Height235 mm
- Spine13 mm
- Edited byShin-Ichi Nishikawa
- Volume editorJohn Morser
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