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- DescriptionBeyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are w firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current kwledge of endothelial functions are 1) observations in the late sixties-early seventies that many n-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is w evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This mograph contains the proceedings of the Advanced Studies Institute on Vascular Endothelium: Receptors and Transduction Mechanisms held in Porto Carras, Greece from June 18-29, 1988.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication22/05/2013
- SubjectLife Sciences: General
- Series TitleNATO Science Series B
- Series Part/Volume Number308
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Note65 black & white illustrations, biography
- Weight618 g
- Width178 mm
- Height254 mm
- Spine17 mm
- Edited byJohn D. Catravas
- Edition StatementSoftcover reprint of the original 1st ed. 1989
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