Even though numerous questions with regard to the pathogenesis of athero sclerosis have not yet been answered, the accumulated evidence indicates significant regression of lesions in experimental animals. This is discussed extensively in this monograph, as are the mechanisms involved in regression of lesions. Whether human atherosclerosis has the potential for regression appears to be the most important, but at the same time the most difficult question to answer. Contrary to experimental atherosclerosis in animals, which can be produced and which can regress within a few months, human lesions in general develop slowly over many years. Therefore, measures aimed at modifying this process may also require many years to be successful. In addition, repeated direct examination of lesions in the human is usually not possible. Nevertheless, recent reports in patients with hyperlipoproteinemias indicate that pronounced and maintained control of hyperlipidemias may lead, even within months, to regression as evidenced by angiography or sophisticated measurements of peripheral circulation. The monograph is divided into two sections. The first will deal with of lipid deposition in the arterial wall, whether atherogenesis : mechanisms or not there is evidence of monoclonal origin of human atherosclerosis plaques, cell culture and factors that stimulate smooth muscle proliferation, and animal models of atherogenesis. This section is concluded with a discussion of dietary factors other than lipids in atherogenesis.
Product Identifiers
Publisher
Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
ISBN-13
9783540085829
eBay Product ID (ePID)
96211467
Product Key Features
Author
R. w. Wissler, E. Stange, G. Schettler
Publication Name
Atherosclerosis-Is It Reversible?
Format
Paperback
Language
English
Subject
Medicine
Publication Year
1978
Type
Textbook
Number of Pages
104 Pages
Dimensions
Item Height
244mm
Item Width
170mm
Item Weight
240g
Additional Product Features
Editor
E. Stange, G. Schettler, R. w. Wissler
Country/Region of Manufacture
Germany
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