The macular caroteids play key roles in eye health and retinal disease. Age-related macular degeneration (AMD), the most common cause of acquired blindness in much of the world, is associated with low levels of macular pigment. Macular pigment is also essential for enhancing visual performance by reducing glare disability and improving photostress recovery. Caroteids and Retinal Disease presents an up-to-date, thorough volume devoted to the chemistry, pathobiology, visual science, and medical and public health significance of the macular caroteids. With contributions from an international group of leading experts, this book covers a range of topics, from macular anatomy to clinical trials. It begins with a chapter tracing the discovery of macular pigment through the more recent functional recognition of caroteids. The text covers AMD risk factors, epidemiology, pathogenesis, and classifications. It reviews evidence from epidemiological studies of relationships between AMD and the caroteids lutein, zeaxanthin, and meso-zeaxanthin, as well as evidence from clinical trials on the effects of macular caroteid supplementation in subjects with AMD and rmal subjects. The book explores the use of molecular genetics in studying macular pigment and AMD pathogenesis; bioavailability of macular pigment; functions of lutein, zeaxanthin, and meso-zeaxanthin; and the identification of macular caroteid binding proteins involved in pigment uptake and transport. It also covers xanthophyll-membrane interactions, and the macular caroteids in human serum and their capacity to protect against AMD. Further, the implications of light distribution on the retina for AMD are discussed. Advancing our understanding of how the macular caroteids enhance vision and prevent vision loss, this book provides a valuable reference for researchers and clinicians involved in the treatment and prevention of retinal disease.
John T. Landrum, PhD, is a professor in the Department of Chemistry and Biochemistry at Florida International University (FIU), where in addition to his role as a faculty member he serves as a director at the Office of Pre-Health Professions Advising for the College of Arts and Sciences. His current research efforts are focused on understanding the mechanisms of biological recognition of individual carotenoids, their absorption and transport, and their role in the developing human eye. In 2004, Professor Landrum's contributions in the field of chemistry were recognized by the FIU with an award for Excellence in Research. He has authored or coauthored 66 articles and chapters in peer-reviewed journals and books. John M. Nolan, Ph.D., is a Fulbright scholar, Howard and European Research Council (ERC) Fellow, adjunct professor of Trinity College Dublin, and principal investigator of the Macular Pigment Research Group (MPRG), Waterford Institute of Technology, Ireland. Professor Nolan was one of the founders of the MPRG, which leads world-class research initiatives in the role of eye nutrition for vision and prevention of blindness and which is now the largest group worldwide studying the macular carotenoids.
Taylor & Francis Inc
Date of Publication
Clinical Medicine: Professional
Place of Publication
Country of Publication
CRC Press Inc
44 black & white illustrations, 12 black & white tables