CURRENTLY SOLD OUT
Best-selling in Textbooks
Save on Textbooks
- AU $37.99Trending at AU $75.40
- AU $64.90Trending at AU $71.21
- AU $93.88Trending at AU $107.51
- AU $100.89Trending at AU $104.10
- AU $68.00Trending at AU $81.46
- AU $55.80Trending at AU $57.00
- AU $99.99Trending at AU $113.28
About this product
- DescriptionThe field of cell cycle regulation is based on the observation that the life cycle of a cell progresses through several distinct phases, G1, M, S, and G2, occurring in a well-defined temporal order. Details of the mechanisms involved are rapidly emerging and appear extraordinarily complex. Furthermore, t only is the order of the phases important, but in rmal eukaryotic cells one phase will t begin unless the prior phase is completed successfully. Che- point control mechanisms are essentially surveillance systems that monitor the events in each phase, and assure that the cell does t progress prematurely to the next phase. If conditions are such that the cell is t ready to progress-for example, because of incomplete DNA replication in S or DNA damage that may interfere with chromosome segregation in M-a transient delay in cell cycle progression will occur. Once the inducing event is properly handled- for example, DNA replication is longer blocked or damaged DNA is repaired-cell cycle progression continues. Checkpoint controls have recently been the focus of intense study by investigators interested in mechanisms that regulate the cell cycle. Furthermore, the relationship between checkpoint c- trol and carcigenesis has additionally enhanced interest in these cell cycle regulatory pathways. It is clear that cancer cells often lack these checkpoints and exhibit gemic instability as a result. Moreover, several tumor suppressor genes participate in checkpoint control, and alterations in these genes are as- ciated with gemic instability as well as the development of cancer.
- PublisherHumana Press Inc.
- Date of Publication14/11/2003
- SubjectLife Sciences: General
- Series TitleMethods in Molecular Biology
- Series Part/Volume Numberv. 241
- Place of PublicationTotowa, NJ
- Country of PublicationUnited States
- ImprintHumana Press Inc.
- Content Notebiography
- Weight820 g
- Width155 mm
- Height235 mm
- Spine26 mm
- Edited byHoward B. Lieberman
This item doesn't belong on this page.
Thanks, we'll look into this.