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About this product
- DescriptionCancer is fundamentally a disease of abrmal cell proliferation: Cancer cells multiply when and where they should t. This proliferation entails escape from rmal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (rmal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such kwledge in cancer therapy.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication04/05/2012
- SubjectClinical Medicine: Professional
- Series TitleCurrent Cancer Research
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Note8 black & white illustrations, 11 colour illustrations, 1 black & white tables, biography
- Weight338 g
- Width155 mm
- Height235 mm
- Spine12 mm
- Edited byGreg H. Enders
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