Jesse is on a UN Youth Ambassadors camp in New York when his subway is rocked by an explosion. Jesse and his three friends, Dave, Anna and Mini, crawl out from the wreckage to discover a city in chaos. Streets are deserted. Buildings are in ruins. Worse, the only other survivors seem to be infected with a virus that turns them into horrifying predators. As the four teenagers navigate their way through a destroyed city, they'll discover the lengths one will go to survive.