Uremia affects every organ system and every aspect of drug disposition by the body. Because the kidney is the major regulator of the internal fluid environment, the physiologic changes associated with renal disease have prounced effects on the pharmacology of many drugs. Containing information on over 450 drugs, the fifth edition of Drug Prescribing in Renal Failure is the most extensive collection of drug-dosing information ever published for patients with impaired renal function. Factors for determining drug dosage are given in easy-to-read tables. This edition contains additional recommendations for supplemental drug dosing during renal replacement therapies and an expanded section on antimicrobial agents that includes many new antiviral agents used in the treatment of HIV infection. Drug Prescribing in Renal Failure is a comprehensive guide to understanding the biochemical and physiologic effects of drugs in patients with renal disease.