This book stresses an analytic and quantitative approach in describing the basic components of physiological regulators and control systems (PRCs). The author presents a grounding in the classical means of designing linear and nlinear systems. There is also cutting-edge material on the potential of PRCs to treat immune system ailments, most tably AIDS and cancer. The focus is on certain wet physiological regulators, such as those using endocrine hormones as parametric control substances. The inherent nlinearity of PRCs is stressed. The author also addresses the problems associated with linear systems that have transport lags. The book describes instances in which exogeus control has been effective, such as the regulation of plasma glucose, mean arterial pressure, and pain. Compartmental analysis is utilized to map the dynamics of drug distribution for more effective results. The author also illustrates the design of closed-loop drug input controllers. Endogeus management is considered in context of the hormonal control of sodium, potassium and calcium ions. The kidneys are key elements in this type of parametic regulation. Also examined is the regulation of plasma glucose concentration. The closed loop treatment of diabetes mellitus is used as an example. The author explores the progress in the use of nlinear dynamic models to describe the human immune system. The book offers simulations that illustrate model validations and the putative control of cancer and HIV proliferation. Endogeus and Exogeus Regulation and Control of Physiological Systems investigates vel, untried immutherapies, which places it on the vanguard of PRC treatment.