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- DescriptionCancer is a complex disease. Only 5-10 per cent of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcigens. The environment includes all that surrounds us, and environmental influences include t only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current kwledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are t necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene-environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world's experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication16/08/2010
- SubjectClinical Medicine: Professional
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Note26 colour tables, biography
- Weight960 g
- Width155 mm
- Height235 mm
- Spine33 mm
- Edited byDeodutta Roy,M. Tevfik Dorak
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