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- DescriptionThis book provides readers with new paradigms on the mutation discovery in the post-geme era. The completion of human and other geme sequencing, along with other new techlogies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Geme Sequencing Consortium stated that The availability of an antated mouse geme sequence w provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future. The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when geme sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have t yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, geme resources, bioinformatics tools, and high throughput techlogies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of gemic cloning and protocols. This book describes new concepts of gene discovery in the post-geme era and the use of streamlined protocols to identify genes of interest. This book helps identify t only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).
- Author BiographyWeikuan Gu received his PhD from Cornell University in 1994 and joined the University of Tennessee Health Science Center as an assistant professor in 2002. Dr. Gu's lab has developed an integrated strategy for the positional cloning of genes, a strategy which has been successfully applied to clone several genes from spontaneous mouse mutations. Yongjun Wang received his MD from Hebei Medical College in 1982 and his MBA from Peking University in 2004. Dr. Wang joined Beijing Tiantan Hospital in 2000 and now serves as the vice president of the hospital.
- PublisherJohn Wiley and Sons Ltd
- Date of Publication12/04/2011
- SubjectMedicine: General
- Place of PublicationHoboken
- Country of PublicationUnited States
- Content NoteIllustrations
- Weight982 g
- Width166 mm
- Height237 mm
- Spine33 mm
- Edited byWang Yongjun,Weikuan Gu
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