Fred Madison has killed his wife Renee, but why does he not remember doing it? Why is Fred opposed to video cameras and what does this have to do with Pete Dayton and his friend, the powerful gangster Mr Eddy? What is the meaning of the strange video tapes Fred and Renee receive every morning? The answers to these questions may be discovered at the end of the Lost Highway... but does it have an end?
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Bill Pullman, David Byrd, Gene Ross, Henry Rollins, Ivory Ocean, Jack Kehler, Jenna Maetlind, John Roselius, Leonard Termo, Louis Eppolito, Michael Massee, Michael Shamus Wiles, Mink Stole, Patricia Arquette, Robert Blake