The prevention and correction of high blood pressure obviously is t an end in itself but a means of preventing cardiovascular complications. It is tempting to res ort to antihypertensive drugs, for the simple reason that current preparations are easy to dose and to take. There is a variety of reasons, however, to take advantage of the antihypertensive potential of npharmaco- logical approaches first. For one thing, the use of tablets tends to accentuate the negative effects oflabelling a subject as hypertensive. The act oftaking tablets per se may elicit a spectrum of subjective adverse effects, as we have learned from placebo-controlled therapeutic trials. Even more importantly, the benefits of antihypertensive drug treatment are largely confined to the reduction of stroke and disease of the large vessels. With regard to incidence of cardiac events, some modest beneficial effects have been registered, such as a decrease in congestive heart failure and in the fatality rate of myocardial infarction. The effects on the incidence of coronary heart disease are only marginal at best. This disappointing finding has been ascribed to various factors: unwanted metabolie effects of anti- hypertensive drugs, inadvertent drops in diastolic pressure interfering with coro- nary perfusion, and, last but t least, failure to eliminate risk factors other than high blood pressure (smoking, alcohol abuse, lipid and glucose disturbanees, obesity, and the hemodynamic disadvantages of a sedentary life). Most of these additional xious factors are refractory to drug treatment and call for modifica- tion of life-style.
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
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Clinical Medicine: Professional
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Springer-Verlag Berlin and Heidelberg GmbH & Co. K