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About this product
- DescriptionIt should t come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does t go far eugh. As it turns out, there is w ather version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be. We have chosen t to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.
- PublisherElsevier Science & Technology
- Date of Publication12/05/1997
- SubjectMedicine: General
- Series TitlePrinciples of Medical Biology
- Series Part/Volume Numberv. 7
- Place of PublicationOxford
- Country of PublicationUnited Kingdom
- ImprintJAI Press Inc.
- Content NoteIllustrations
- Weight1400 g
- Width150 mm
- Height230 mm
- Spine19 mm
- Edited byEdward Bittar,Neville Bittar
- Contained items statement2 Hardbacks
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