Merrhagia is defined as heavy menstrual loss. Its main determinant of management is the impact of merrhagia on the woman's quality of life. This book examines the history of merrhagia, which should elucidate the temporal aspects of the heavy menstrual blood loss and may shed light on the etiology of merrhagia. The authors further provide instructions on how to examine and treat women with merrhagia. Furthermore, the book outlines a diagstic approach and concentrates on different therapies like combined oral contraceptive pills in contrast with surgical management. With an effective treatment management, it is possible to better achieve the diagstics of heavy menstrual bleeding (HMB) although areas that need further research are highlighted. The clinical use of NF-kappaB (NF-kB) inhibitors, which play an important role in the regulation of the amount of menstrual bleeding and pain are also explored. In addition to merrhagia, the authors of this book examine dysmerrhea, pain associated with menstruation. It is also the most prevalent symptom in women with the painful condition of endometriosis. Ilaria Erasmo and Simone Ferrero examine the types of therapy for endometriosis-related dysmerrhea and the various hormonal treatments shown to effectively and safely relieve pain, which they argue should be based on the preference of the patients, on the incidence of adverse effects and on the costs of treatment.