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About this product
- DescriptionAlthough less common than alpha-ami acids, n-alpha-ami acids-where the ami group is t on the carbon immediately adjacent to the carboxyl group but is attached to ather carbon in the chain (for example, the ss, gamma, delta carbon)-are components of biologically important molecules, are significant in the pharmaceutical industry, and are useful starting materials for many areas of organic chemistry. Since the publication of the first edition of this book nearly 20 years ago, synthetic work devoted to the preparation of n- alpha-ami acids has expanded greatly. Methods of Non-alpha-Ami Acid Synthesis, Second Edition has been extensively rewritten and reorganized, providing an up-to-date review of strategies and methods for n-alpha-ami acid synthesis, particularly those ami acids that are key synthetic intermediates or important compounds in their own right. It focuses on acyclic ami acids of C3-C10, but also amialkaic carboxylic acids, amialkeic acids, and amialkyic acids. The new edition contains many updated references and has a greater emphasis on the biological importance of n-alpha-ami acids. In addition to an array of synthetic methods, the book offers discussions on why n-alpha-ami acids are important. The book covers synthetic methods that rely on substituent refunctionalization, the conversion of cyclic precursors to acyclic ami acids, conjugate addition reactions, and elate anion reactions and condensation reactions that lead to n-alpha-ami acids. It also examines reactions and strategies that lead to good diastereoselectivity and enantioselectivity during synthesis. A chapter devoted to biologically important ami acids includes separate sections on GABA, GABOB, carnitine, DAVA, statine, and other significant ami acids as well as a new section on peptides and proteins that contain n-alpha-ami acids. The final chapter addresses amicyclic and heterocyclic ami acids.
- Author BiographyMichael B. Smith attended Purdue University, graduating with a Ph.D. in Organic Chemistry. His postdoctoral work took place at the Arizona State University with George R. Pettit and at the Massachusetts Institute of Technology with Sidney Hecht. Dr. Smith joined the faculty at the University of Connecticut in 1977, where he now holds the rank of full professor. He is the author of the 5th-7th editions of March's Advanced Organic Chemistry, Organic Synthesis (3rd edition), and Organic Chemistry: An Acid-Base Approach.
- Author(s)Michael Bryant Smith
- PublisherTaylor & Francis Inc
- Date of Publication30/10/2013
- SubjectLife Sciences: General
- Place of PublicationBosa Roca
- Country of PublicationUnited States
- ImprintCRC Press Inc
- Content Note410 black & white illustrations
- Weight476 g
- Width156 mm
- Height235 mm
- Spine20 mm
- Format DetailsUnsewn / adhesive bound
- Edition Statement2nd Revised edition
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