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About this product
- DescriptionThis volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does t act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulimimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that w gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication19/03/2012
- SubjectNatural History: Animal & Wildlife
- Series TitleAdvances in Experimental Medicine and Biology
- Series Part/Volume Number293
- Place of PublicationNew York
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Notebiography
- Weight1023 g
- Width178 mm
- Height254 mm
- Spine27 mm
- Edited byDerek LeRoith,Mohan K. Raizada
- Format DetailsTrade paperback (US)
- Edition StatementSoftcover reprint of the original 1st ed. 1991
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