Neurotoxicity of Namaterials and Namedicine presents an overview of the exciting research in neurotoxicity and namaterials. Namaterials have been extensively used in medicine, including diagsis probes, drug carriers, and embedded materials. While some have been approved for clinical use, most namaterials are waiting to be transferred from lab to clinic. However, the toxicity is a main barrier that restricts the translation. This comprehensive book includes chapters on the most commonly used individual naparticles, with information on the applications, neurotoxicity, and related mechanisms of each, providing the most in-depth and current information available. The book examines the pathways that namaterials enter into, and eliminate, from the brain, along with the strategies that could reduce the neurotoxicity of namaterials. Providing a background to the subject, detailed information, and ideas for future directions in research, the book is essential for students and researchers in toxicology, and for those in medicine, neurology, pharmacology, pharmaceutical science, and materials science who are researching namaterials.
Prof. Xinguo Jiang obtained B. S. in Pharmacy from Shanghai First Medical College in July 1982. Then he worked in the Department of Pharmaceutics in Fudan University (original Shanghai First Medical College) since Oct 1986. During Jan and Jul in 1996, he was a guest professor in the Department of Pharmacy in Nagasaki University (Japan). He also served as the vice-editor for Chinese Journal of Clinical Pharmacy and editorial board member for other eight journals including Acta Pharmaceutica Sinica and Chinese Pharmaceutical Journal. Jiang's research interests focus on the development of novel drug delivery system especially for brain-targeting drug delivery. Served as the Principal Scientist, Prof. Jiang received a research grant form State Plan for Development of Basic Research in Key Areas. He also has won eight research grants from National Natural Science Foundation of China and five research grants from Shanghai government. He has accomplished over 70 R&D projects on the novel drug delivery systems under cooperation with pharmaceutical companies. Jiang has published over 120 research papers in peer-reviewed journals and fifteen patents. And he has developed three marked formulations. Served as guest editor, he edited two theme issues for Pharmaceutical Research and Current Pharmaceutical Biotechnology. He also wrote several book chapters and edited three books (in Chinese). Dr. Huile Gao received his PhD in Pharmaceutics from School of Pharmacy, Fudan University in 2013 under the supervision of Prof. Xinguo Jiang. Then he joined the West China School of Pharmacy, Sichuan University as an Instructor in July 2013 and was promoted to an Associate Professor in July 2014. Dr. Gao's research interests focus on the design, synthesis, characterization and evaluation of stimuli responsive nanomaterials for drug and imaging probe delivery to improve treatment and diagnosis of human diseases especially tumor and brain diseases. He has published over 50 peer-reviewed articles. His research is supported by National Natural Science Foundation of China (81373337, 81402866), Excellent young scientist foundation of Sichuan University (2015SCU04A14) and 4 other grants. His doctorial dissertation has been awarded as Excellent Doctorial Dissertation of Shanghai in 2015. He was awarded as Young Excellent Pharmaceutics Scientist in 2015.