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HIGHLY COMMENDED IN THE 2016 BMA MEDICAL BOOK AWARDS! Instructors' comments on new, 3rd edition: I LOVED the book. I've never seen anything like it, and I've reviewed a lot of genetics texts. The way that cases are presented throughout is extremely vel. I am greatly pleased with the revisions. In my opinion, there is an increased clarity in the text (which will serve students well), and many welcomed updates based on current literature. Good job! I LIKE IT A LOT!! The book looks good and we will certainly be recommending it for our medical genetics course this autumn. This is a fantastic book that I enjoy so much teaching from. I have been reviewing the book. I think it is a great teaching tool since you can follow a case from beginning to end. I have used this book every year since the first edition was published and it is a perfect fit for my human genetics course. I will definitely continue to use it. It's great. I will recommend the book as a main text for the medical student class. In the few years since the previous edition technical progress, especially the widespread use of whole-geme techlogies, has brought many advances in the understanding, diagsis and treatment of genetic disease. As a result, most chapters have been substantially rewritten and updated to reflect this. The unique structure and format remains the same, but significant new material has been added to cover: the widespread use of next-generation sequencing as a routine diagstic toolthe checking of a patient's whole exome for the cause of their problemninvasive prenatal diagsis by next-generation sequencing of free fetal DNA in the maternal circulationa new integrated treatment of epigeneticsmosaicism, `RASopathies' and disorders of the spliceosome are described in new Disease boxesdysmorphology in more detail New Clinical Genetics continues to offer the most invative case-based approach to modern genetics. It is used worldwide as a textbook for medical students, but also as an essential guide to the field for genetic counselors, physician assistants, and clinical and nurse geneticists. Reviews of earlier editions: This book provides a wonderful case-based learning environment. There are also self-assessment questions. Students are t given model answers but are provided with guidance on how to work out the correct answers for themselves. Excellent! Human Genetics This book is a very valuable tool that will be used by future geneticists all over Europe and beyond, both as a teaching material and as a source of excellent kwledge. European Journal of Human Genetics