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Oxidative Stress and Vascular Disease by John F. Keaney (Hardback, 1999)

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One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces t only coronary disease mortality but also all- cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is w accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of mocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters ...the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cant be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Product Identifiers

Publisher
Kluwer Academic Publishers
ISBN-10
0792386787
ISBN-13
9780792386780
eBay Product ID (ePID)
96352458

Product Key Features

Author
John F. Keaney
Format
Laminated Cover, Hardback
Language
English
Subject
Clinical Medicine: Professional
Type
Textbook

Dimensions

Weight
1610g
Height
234mm
Width
156mm

Additional Product Features

Spine
22mm
Series Part/Volume Number
V. 224
Series Title
Developments in Cardiovascular Medicine
Content Note
Biography
Date of Publication
01/12/1999
Country of Publication
United States
Genre
Clinical Medicine: Professional

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Oxidative Stress and Vascular Disease by John F. Keaney (Hardback, 1999)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Time Management by Peter Quarry (Paperback, 1986)

Complete Illustrated Encyclopedia of Dinosaurs & Prehistoric Creatures by Dixon Dougal (Paperback, 2014)

Polyvagal Exercises for Safety and Connection: 50 Client-Centered Practices by Deb Dana (Paperback, 2020)

Save on Adult Learning & University

Ford Falcon EF EL / Fairlane NF NL 1994 - 1998 Workshop Manual

Netter Atlas of Human Anatomy: Classic Regional Approach

Michael Price Nick Vandome Windows 11 for Seniors in easy steps (Paperback)

BORN IN 1971?... 1951?BIRTHDAY...Australian Social History....Chrisi, Birthdays

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