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About this product
- DescriptionThe human race has ermous he terogenei ty, founded on genetic and environmental sources. Variability, therefore, is a vital dimension in any consideration of human risk assessment. In the estimation of risks, current methods of extrapolation based upon converting the response of a median man are inadequate, as they igre phetypic variation and there- fore, susceptible subgroups. There is a growing literature defining the extent of human variation in rmal populations; thus, the rmal young adult population may have 10-20% kwn hyperreactors. How far can we igre human variability in risk assessment? Should we be concerned with susceptible groups, and how can we modify the risk assessment analysis accordingly? The aim of our meeting was to bring together experts from the fields of human epidemiology, toxicology, aging, genetics, carci- genesis and teratology, and to provide a forum in which we might assimi- late kwledge of human heterogeneity as a coherent whole. Since the resolution and obligations of risk assessment, in the last analysis, are a political process, we also involved representatives from the legal field, the unions, and the regulatory agencies. We are most grateful for financial support from the National Institute on Aging; the u. S. Environmental Protection Agency; the U. S. Department of Energy; FDA - National Center for Toxicological Research; The Council for Tobacco Research-USA, Inc; Johnson and Johnson; Merck Sharp and Dohme Research Laboratories; and Associated Universities, Inc. We thank our Symposium Coordinator, Ms.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication14/03/2013
- SubjectMedicine: General
- Series TitleBasic Life Sciences
- Series Part/Volume Number43
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Note27 black & white illustrations, biography
- Weight610 g
- Width178 mm
- Height254 mm
- Spine17 mm
- Edited byAvril D. Woodhead
- Format DetailsTrade paperback (US)
- Edition StatementSoftcover reprint of the original 1st ed. 1988
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