Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in t only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current kwledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma. The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data. Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turver markers, and initial findings obtained with desumab.
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Date of Publication
Recent Results in Cancer Research
Series Part/Volume Number
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Springer-Verlag Berlin and Heidelberg GmbH & Co. K