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Principles of Asymmetric Synthesis: Volume 14 by J. Aube, R.E. Gawley (Paperback, 1996)

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The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms.A chapter on Analytical Methods provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented.Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. An http://asnetserver.as.miami.edu/rgawley/Book.htmlupdated list of references for this book can also be viewed.

Product Identifiers

Publisher
Elsevier Science & Technology
ISBN-13
9780080418759
eBay Product ID (ePID)
95584838

Product Key Features

Author
J. Aube, R.E. Gawley
Publication Name
Principles of Asymmetric Synthesis: Volume 14
Format
Paperback
Language
English
Subject
Chemistry
Publication Year
1996
Type
Textbook
Number of Pages
394 Pages

Dimensions

Item Weight
760g

Additional Product Features

Title_Author
J. Aube, R.E. Gawley
Series Title
Tetrahedron Organic Chemistry
Country/Region of Manufacture
United Kingdom

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Principles of Asymmetric Synthesis: Volume 14 by J. Aube, R.E. Gawley (Paperback, 1996)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Time Management by Peter Quarry (Paperback, 1986)

Complete Illustrated Encyclopedia of Dinosaurs & Prehistoric Creatures by Dixon Dougal (Paperback, 2014)

Save on Adult Learning & University

Ford Falcon EF EL / Fairlane NF NL 1994 - 1998 Workshop Manual

Netter Atlas of Human Anatomy: Classic Regional Approach

Michael Price Nick Vandome Windows 11 for Seniors in easy steps (Paperback)

BORN IN 1971?... 1951?BIRTHDAY...Australian Social History....Chrisi, Birthdays

It's Not You: How to Identify and Heal from NARCISSISTIC People by Ramani Durvas

Ethical Practice in Applied Psychology 1st Edition by Christopher Boyle (English

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