Progressive multiple sclerosis places huge burdens on individuals, carers and society and treatment options are currently limited. However, there have been significant recent advances in understanding progressive disease and this book draws together the field into a single accessible, clinically focused text. Progressive Multiple Sclerosis sets out the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. The biological processes underlying disease progression are elucidated and specific pathophysiological mechanisms. The basic science of axonal degeneration and clinical understanding of progressive multiple sclerosis is discussed in the context of emerging and future therapies for disease progression as well as discussion of how trials might be conducted for progressive multiple sclerosis and an overview of biomarkers for the disease. Existing symptomatic therapies for progressive multiple sclerosis are discussed in detail.
Dr Alastair Wilkins is Senior Lecturer in Neurology, University of Bristol, and Consultant Neurologist at Frenchay Hospital, Bristol, UK. He researches axonal injury in multiple sclerosis and related disorders.