Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but t on their application s to toxic chemicals. This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on chemical mutagens and carcigens. It synthesizes the body of kwledge and recent advances in this rapidly emerging field through the contributions of leading experts from around the world. Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcigens focuses on the use of QSAR modeling in predicting and designing compounds for synthesis and testing of cancer drugs. The authors clearly show how QSAR can contribute to the elucidation of mechanisms, to identifying toxic chemicals solely by their chemical structure, and to the design of safer chemicals. The contents include a general introduction to QSAR theory and extensive reviews of virtually all existing QSAR models.
Taylor & Francis Inc
Date of Publication
Clinical Medicine: Professional
Place of Publication
Country of Publication
CRC Press Inc
43 black & white illustrations, 30 black & white tables