Preston Brandymire's world has been tossed on its head. Expelled from middle school, he and his sister Paige have been branded as freaks. At their new school, they learn that everybody has freakish abilities just like them, but that they alone hold the key to the school's dark past. Seeking this key, a murderous temptress pursues them along with a legion of dark mutants. What common thread do they share? What secrets does She hide? Can they stop her before She destroys the one thing keeping her evil in check?