Vor die Therapie setzten die Gotter die Diagse. Otto NiigeJi Renal biopsy has decisively enriched renal diagstics. Kidney diseases may be monitored during their entire course, and new techniques - such as immufluorescence and electron microscopy - may be systematically applied, resulting in vel insights into the morphogenesis, pathogenesis, and etiology of kidney lesions. These insights, in turn, have served as new starting points, in the spirit of the quotation above, for the institution of causal therapy by the clinician. This work presents our findings based on 20 years of experience in evaluating renal biopsies. As of the end of 1974, our computer-supported, systematic clinical, morphologic, and follow-up evaluation of case material consisted of over 2000 biopsies, including 679 examined by electron microscopy and 400 by immufluorescence microscopy. The subsequent 500 biopsies (400 studied by electron microscopy and 300 by immufluorescence) were con- sidered qualitatively only. In order to enhance qualitative findings with quantitative data, it was necessary to devise new methods for quantifying electron-microscopic findings. Additionally, we attempted to correlate cyto- logic and immufluorescent observations to integrate the isolated findings of electron microscopy into a vital cytologic pattern of reactions. We also attempted to evaluate the almost overwhelming flood of publications, especially those appearing within the last 10 years. The idea for this book was conceived a decade ago. At that time, however, our own experience in renal biopsy diagstics seemed insufficient to sup- port such a major undertaking.
Georges M. Thiel, H. U. Zollinger, M. J. Mihatsch
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
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Springer-Verlag Berlin and Heidelberg GmbH & Co. K