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About this product
- DescriptionThe papers contained in this volume were presented ati the Golden Jubilee Cancer Prevention Conference, The Biology and Prevention of Aerodigestive Tract Cancers, sponsored by The University of Texas M. D. Anderson Cancer Center in Houston, Texas, February 21-23, 1991. The purpose of the conference was to further the understanding of the biology, epidemiology, and prevention of aerodigestive tract cancers. Advances in under- standing the biology of aerodigestive tract cancers have led to successful early chemoprevention trials. Chemopreventive agents in current use are capable 9f reversing premalignant lesions, as well as reducing the number of second primary cancers of the head and neck. These trials hold the promise that effective prevention methods for these cancers will be forthcoming in the foreseeable future. Carcigenic exposures appear to affect the entiry epithelial lining of the upper aerodigestive tract, a phemena described as field cancerization. This process contributes to the development of both synchrous and metachrous aerodigestive tract cancers. It also provides a sound rationale for the chemoprevention of these cancers. Animal models are important for identifying the critical components of field cancerization and for testing potentially new chemopreventive agents and regimens. The hamster lung carcigen- esis model and the hamster cheek model are discussed. Aerodigestive tract cancers account for about 20% of newly diagsed invasive cancers. Cigarette smoking and alcohol consumption are the most important risk factors for these cancers.
- PublisherSpringer-Verlag New York Inc.
- Date of Publication29/10/2012
- SubjectClinical Medicine: Professional
- Series TitleAdvances in Experimental Medicine and Biology
- Series Part/Volume Number320
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Notebiography
- Weight367 g
- Width178 mm
- Height254 mm
- Spine10 mm
- Edited byGuy R. Newell,Waun Ki Hong
- Format DetailsTrade paperback (US)
- Edition StatementSoftcover reprint of the original 1st ed. 1992
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