The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the menclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity.
Dr. Parham was born in London and read natural sciences at Cambridge University. He began study of the genetic basis of HLA polymorphism in 1973 and has continued this line of research ever since. Dr. Parham is currently Professor of structural biology and microbiology and immunology at Stanfor University. Linda Barber's doctoral and post-doctoral studies examined the structure and function of MHC classI and classII molecules with emphasis on the impact of polymorphism on peptides bound and presented for immune surveillance. Dr. Barber's current interests focus on utilizing our understanding of the role of MHC molecules in T cell and NK cell function to develop improved prophylatic and therapeutic strategies for manipulating immune responses.