The Neurobiology of Huntington's Disease: Applications to Drug Discovery by Taylor & Francis Inc (Hardback, 2009)
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About this product
- DescriptionIn 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human gemics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our kwledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its mogenic nature confers ermous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: * Covers the latest research approaches in genetics, gemics, and proteomics, including high-throughput and high-content screening * Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders * Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators w brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families.
- Author BiographyDuke University Medical Center, Durham, North Carolina, USA Buck Institute for Age Research, Novato, California, USA
- PublisherTaylor & Francis Inc
- Date of Publication15/11/2009
- SubjectMedicine: Textbooks & Study Guides
- Series TitleFrontiers in Neuroscience
- Series Part/Volume Numberv. 45
- Place of PublicationBosa Roca
- Country of PublicationUnited States
- ImprintCRC Press Inc
- Content Note36 black & white illustrations, 10 black & white tables
- Weight612 g
- Width156 mm
- Height235 mm
- Spine23 mm
- Edited byDonald C. Lo,Robert E. Hughes
- Format DetailsUnsewn / adhesive bound
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