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The Polyol Paradigm and Complications of Diabetes by Margo P. Cohen (Paperback, 2011)

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In the last decade, it has become increasingly evident that the clini- cal and morphologic changes underlying many of the complications of diabetes, including cataract formation, retinopathy, nephropathy, neuropathy, and macrovascular disease, are preceded by a variety of disturbances of biochemical and physiologic origin. Dr. Cohen has recently written a superb monograph, entitled Diabetes and Protein Glycosylation: Measurement and Biologic Relevance, in which she thoroughly explores how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for main- tenance of long-term euglycemia. In the present volume, The Polyol Paradigm and Complications of Diabetes, she reviews, in a most succinct and thorough manner, how another biochemical mechan- ism, involving the polyol pathway, is involved in the pathogenesis of such diabetes complications as retinopathy, neuropathy, nephropa- thy, and cataract formation. Dr. Cohen gives us a clearly written and comprehensive mono- graph, reviewing the chemistry of the polyol pathway and of the aldose reductase inhibitors, and the pathophysiologic significance of increased polyol pathway activity in a variety of tissues affected by Vlll Foreword diabetes mellitus. She insightfully describes the relationship of increased polyol pathway activity to altered metabolism of inositol- containing phospholipids and to changes in various tissue concentra- tions of myo-inositol. Finally, she provides us with a careful review of the existing experimental and clinical studies with a variety of different aldose reductase inhibitors that have been and are being performed in the hope of preventing or reversing long-term compli- cations of diabetes.

Product Identifiers

Publisher
Springer-Verlag New York Inc.
ISBN-13
9781461291084
eBay Product ID (ePID)
117488001

Product Key Features

Author
Margo P. Cohen
Publication Name
The Polyol Paradigm and Complications of Diabetes
Format
Paperback
Language
English
Subject
Medicine, Chemistry, Biology, Psychiatry
Publication Year
2011
Type
Textbook
Number of Pages
143 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Item Weight
254g

Additional Product Features

Title_Author
Margo P. Cohen
Country/Region of Manufacture
United States

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The Polyol Paradigm and Complications of Diabetes by Margo P. Cohen (Paperback, 2011)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Time Management by Peter Quarry (Paperback, 1986)

Complete Illustrated Encyclopedia of Dinosaurs & Prehistoric Creatures by Dixon Dougal (Paperback, 2014)

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Save on Adult Learning & University

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