Threads of Destiny: A Surgeon's Odyssey by Charles Marks describes the developments in cardiovascular and transplantation surgery within the parameters of his own surgical career. The author reviews his migration from Ukraine and Lithuania to Cape Town, South Africa where he completed his medical studies. Many years of unique surgical training and practice take him on a prolonged journey that encompasses challenges and opportunities in Southern Africa, England, United States and Israel. Written from an insider's vantage point, Threads of Destiny provides a thoughtful account of medical education and describes interesting clinical challenges that ring with verisimilitude and drama. Throughout his sojourn Dr. Marks is fortified by the love and support of a happy home life provided by his wife, Joyce, as they raise their four sons and observe the growth and development of their American-born grandchildren.