Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins. Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the vel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. Covering topics such as white matter neurobiology, mild cognitive dysfunction and Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagsis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic invations aimed at prevention of white matter damage and restoration of myelin. This unique book is an absolute must-have for all medical specialists and consultants in neurology, neuropsychiatry, and neuropsychology involved with the growing challenge of dementia.
Christopher M. Filley is Professor of Neurology and Psychiatry and Director of the Behavioral Neurology Section at the University of Colorado School of Medicine, Aurora, CO, and Neurology Service Chief at the Denver Veterans Affairs Medical Center, Denver, CO, USA.