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Agammaglobulinemia by Vassilios Lougaris, Alessandro Plebani (Hardcover, 2015)

About this product

About this product

Product Information

This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton's tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients' management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book's closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

Product Identifiers

Publisher
Springer International Publishing Ag
ISBN-13
9783319227139
eBay Product ID (ePID)
216367677

Product Key Features

Author
Vassilios Lougaris, Alessandro Plebani
Publication Name
Agammaglobulinemia
Format
Hardcover
Language
English
Subject
Medicine, Biology
Publication Year
2015
Type
Textbook
Number of Pages
119 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
4
Item Weight
3497g

Additional Product Features

Series Title
Rare Diseases of the Immune System
Country/Region of Manufacture
Switzerland
Editor
Alessandro Plebani, Vassilios Lougaris

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