This volume contains the papers presented at the Inter- national Symposium on Cirrhosis, Hepatic Encephalopathy and Ammonium Toxicity , held in Valencia, Spain, November 27-29, 1989. Hepatic cirrhosis as well as other liver failures usual- ly lead to hepatic encephalopathy which is an important cause of death in occidental countries. However the molecular bases of the pathogenesis of hepatic encephalopathy remain unclear and several hypotheses have been proposed. Hyperammonemia is considered one of the main factors responsible for the mediation of hepatic encephalopathy. Therefore, a part of the book is devoted to the effects of hyperammonemia on cerebral function, ammonia and amino acid metabolism, brain microtobules, astrocytes and synaptic trans- mission and their possible role in the pathogenesis of hepatic encephalopathy. Carnitine has a remarkable protective effect against acute ammonium intoxication. Thus some results regarding this effect are also presented, as well as the clinical use of car- nitine. The alterations of the metabolism of ammonia and of seda- tives in liver diseases and their clinical implications are also discussed. The possible role of altered GABA-ergic neurotransmission on the pathogenesis of hepatic encephalopathy has received considerable attention recently. Results of these studies and those on benzodiazepine receptor ligands are presented as well as those on the hypothesis of the role of altered synaptic plasma membrane on the pathogenesis of hepatic encephalopathy.
Product Identifiers
Publisher
Springer-Verlag New York Inc.
ISBN-13
9781468458282
eBay Product ID (ePID)
189375167
Product Key Features
Author
Santiago Grisolia, Vicente Felipo, Maria-Dolores Minana
Publication Name
Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity
Format
Paperback
Language
English
Subject
Medicine, Chemistry, Biology
Publication Year
2012
Type
Textbook
Number of Pages
284 Pages
Dimensions
Item Height
254mm
Item Width
178mm
Volume
272
Item Weight
552g
Additional Product Features
Series Title
Advances in Experimental Medicine and Biology
Country/Region of Manufacture
United States
Editor
Maria-Dolores Minana, Vicente Felipo, Santiago Grisolia
Best Selling in Adult Learning & University
Current slide {CURRENT_SLIDE} of {TOTAL_SLIDES}- Best Selling in Adult Learning & University